Dialkylamino and nitrogen heterocyclic analogues of hexadecylphosphocholine and cetyltrimetylammonium bromide: Effect of phosphate group and environment of …

…, F Ondriska, J Valentová, I Lacko, M Bukovský…

文献索引：Lukac, Milos; Mojzis, Jan; Mojzisova, Gabriela; Mrva, Martin; Ondriska, Frantisek; Valentova, Jindra; Lacko, Ivan; Bukovsky, Marian; Devinsky, Ferdinand; Karlovska, Janka European Journal of Medicinal Chemistry, 2009 , vol. 44, # 12 p. 4970 - 4977

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被引用次数: 20

摘要

A series of dialkylamino and nitrogen heterocyclic analogues of hexadecylphosphocholine and cetyltrimethylammonium bromide have been synthesized. The prepared compounds exhibit significant cytotoxic, antifungal and antiprotozoal activities. Alkylphosphocholines possess higher antifungal activity against Candida albicans in comparison with quaternary ammonium compounds. However, quaternary ammonium compounds exhibit significant ...