Novel Concepts in Directed Biaryl Synthesis, IX. Synthesis and Structure of Benzonaphthopyranones, Useful Bridged Model Precursors for Stereoselective Biaryl …

G Bringmann, T Hartung, L Goebel…

文献索引：Bringmann, Gerhard; Hartung, Thomas; Goebel, Lothar; Schupp, Olaf; Ewers, Christian L. J.; et al. Liebigs Annalen der Chemie, 1992 , # 3 p. 225 - 232

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摘要

Abstract A practicable two-step procedure for the preparation of a series of lactone-type bridged biaryls 7 as favorable substrates for subsequent atropisomer-selective ring-opening reactions is described. Due to the efficiency of the coupling step, which tolerates even a tert- butyl group next to the biaryl axis and avoids problems of regioselectivity, a variety of differently substituted representatives is prepared. These cover a broad range of steric ...