Seven analogues of medetomidine and naphamline were synthesized and evaluated for their a1 (aorta) and a2 (platelet) activities. The analogues were composed of 2-and 4- substituted imidazoles and imidazolines attached through a methylene bridge to either the 1- or 2-naphthalene ring system. In general the 1-naphthalene analogues were the most potent inhibitors of epinephrine-induced platelet aggregation. Of coneiderable interest was the ...
