Synthesis and. alpha.-adrenergic activities of 2-and 4-substituted imidazoline and imidazole analogs

Y Amemiya, SS Hong, BV Venkataraman…

文献索引：Amemiya; Hong; Venkataraman; Patil; Shams; Romstedt; Feller; Hsu; Miller Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 750 - 755

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被引用次数: 30

摘要

Seven analogues of medetomidine and naphamline were synthesized and evaluated for their a1 (aorta) and a2 (platelet) activities. The analogues were composed of 2-and 4- substituted imidazoles and imidazolines attached through a methylene bridge to either the 1- or 2-naphthalene ring system. In general the 1-naphthalene analogues were the most potent inhibitors of epinephrine-induced platelet aggregation. Of coneiderable interest was the ...