Reduction-methylation of derivatives of 3-buten-2-one

LE Hightower, LR Glasgow, K Stone…

文献索引：Hightower,L.E. et al. Journal of Organic Chemistry, 1970 , vol. 35, p. 1881 - 1886

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被引用次数: 13

摘要

The lithium-liquid ammonia reduction and reduction-methylation of 3-buten-2-one derivatives trans-4-phenyl-3-buten-2-one (la j, 3-methyl-4-phenyl-3-buten-2-one (lb), and 4- methyl-3-penten-2-one (IC) have been investigated. In each case the only monomethylation product obtained was derived from the specific lithium enolate generated reductively. Unlike 2-cyclohexenone derivatives, open-chain enones la-lc also gave much polymethylation, ...