Abstract The first total synthesis of (+)-murolic acid is accomplished in 17 steps from ester 9 in 14.8% overall yield. The key steps involve asymmetric dihydroxylation, orthoester Johnson–Claisen rearrangement and α-methylenation using Stiles reagent. A beneficial late stage β-epimerization reverted a stereodivergent relay to a stereoconvergent completion of an efficient synthesis of (+)-murolic acid.
