Synthesis and structure-activity relationship of α-sulfonylhydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis

V Aranapakam, GT Grosu, JM Davis, B Hu…

文献索引：Journal of Medicinal Chemistry, , vol. 46, # 12 p. 2361 - 2375

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被引用次数: 60

摘要

... Journal of Medicinal Chemistry. ... Chemistry. The compounds of the present investigation, namely, substituted α-phenylsulfonylhydroxamide derivatives, can be conveniently prepared by alkylating the appropriately substituted ...