CNS and antimalarial activity of synthetic meridianin and psammopemmin analogs

…, T Mutka, P Maignan, JB McClintock, CD Amsler…

文献索引：Lebar, Matthew D.; Hahn, Kristopher N.; Mutka, Tina; Maignan, Patrick; McClintock, James B.; Amsler, Charles D.; Van Olphen, Alberto; Kyle, Dennis E.; Baker, Bill J. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 19 p. 5756 - 5762

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被引用次数: 14

摘要

The marine invertebrate-derived meridianin A, the originally proposed structure for psammopemmin A, and several related 3-pyrimidylindole analogs were synthesized and subsequently investigated for central nervous system, antimalarial, and cytotoxic activity. A Suzuki coupling of an indoleborate ester to the pyrimidine electrophile was utilized to form the natural product and derivatives thereof. The 3-pyrimidineindoles were found to prevent ...