New nonpeptide angiotensin II receptor antagonists. 1. Synthesis, biological properties and structure-activity relationships of 2-alkylbenzimidazole derivatives

…, DA Roberts, ST Russell, DA Thomason

文献索引：Thomas; Allott; Gibson; Major; Masek; Oldham; Ratcliffe; Roberts; Russell; Thomason Journal of Medicinal Chemistry, 1992 , vol. 35, # 5 p. 877 - 885

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被引用次数: 97

摘要

On the basis of an extension of the literature lead 1, a series of benzimidazoles have been synthesized and shown to be angiotensin I1 (AII) receptor antagonists. The structure-activity relationships of these new antagonists have been explored and the key binding interactions defined. Molecular mechanics calculations were carried out on analogues of imidazole An antagonists and conformationally restricted analogues were synthesized. The ...