(.+-.)-Carbocyclic 5'-nor-2'-deoxyguanosine and related purine derivatives: synthesis and antiviral properties

SD Patil, M Koga, SW Schneller, R Snoeck…

文献索引：Patil, Sharadbala D.; Koga, Masakazu; Schneller, Stewart W.; Snoeck, Robert; Clercq, Erik De Journal of Medicinal Chemistry, 1992 , vol. 35, # 12 p. 2191 - 2195

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被引用次数: 27

摘要

Unlike compound 1, which has been shown to have marked activity against herpes viruses,'- 3 compounds 2-4 did not prove inhibitory to these (HSV-1, HSV-2, VZV, and CMV) and other viruses (W and VSV)(Tables I and 11) that included the wild-type thymidine kinase-positive (TK+) variants of HSV-1 or VZV and thymidine kinase-