Tetrahedron

Synthesis of cyclic ethers utilizing a cyclization–fragmentation strategy

DA Ockey, DR Lane, JA Seeley, NE Schore

文献索引：Ockey, Denise A.; Lane, David R.; Seeley, Juliette A.; Schore, Neil E. Tetrahedron, 2000 , vol. 56, # 5 p. 711 - 717

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被引用次数: 9

摘要

A variety of cyclic ethers have been prepared via both solution phase and polymer- supported sequences of 3+ 2 cycloaddition of nitrile oxides to alkenes and dienes to give isoxazolines, followed by electrophile-induced cyclization. Library generation by alkylative elaboration of isoxazolines was unsuccessful, but both simple and substituted dienes were found suitable for polymer-supported formation of cyclic ethers of ring sizes five through ...