Synthesis and characteristics of biodegradable pyridinium amphiphiles used for in vitro DNA delivery
A Roosjen, J Šmisterová, C Driessen…
文献索引：Roosjen, Astrid; Smisterova, Jarmila; Driessen, Cecile; Anders, Joachim T.; Wagenaar, Anno; Hoekstra, Dick; Hulst, Ron; Engberts, Jan B. F. N. European Journal of Organic Chemistry, 2002 , # 7 p. 1271 - 1277
Abstract Pyridinium amphiphiles have found practical application for the delivery of DNA into eukaryotic cells. A general synthetic method starting from (iso) nicotinoyl chloride has been devised for the preparation of pyridinium amphiphiles based on (bio) degradable esters, allowing structural variation both in the hydrophobic part and in the headgroup area. By means of differential scanning calorimetry, transmission electron microscopy and UV ...
