Organic process research & development

Development of a continuous enzymatic process for the preparation of (R)-3-(4-fluorophenyl)-2-hydroxy propionic acid

J Tao, K McGee

文献索引：Organic Process Research and Development, , vol. 6, # 4 p. 520 - 524

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被引用次数: 45

摘要

... The key to the process is the use of a continuous membrane reactor which was simple in ... to pH 3.0 with 2 N HCl and extracted with MTBE (3 × 5.0 L). The organic layer was ... To check optical purity, 1 was converted to 7 by a standard esterification procedure, and the enantiomeric ...