Novel sulfonanilide analogues suppress aromatase expression and activity in breast cancer cells independent of COX-2 inhibition

B Su, ES Diaz-Cruz, S Landini…

文献索引：Su, Bin; Diaz-Cruz, Edgar S.; Landini, Serena; Brueggemeier, Robert W. Journal of Medicinal Chemistry, 2006 , vol. 49, # 4 p. 1413 - 1419

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被引用次数: 44

摘要

Aromatase is a particularly attractive target in the treatment of estrogen receptor positive breast cancer. Aromatase levels in breast cancer cells are enhanced by prostaglandins and reduced by COX inhibitors. The synthesis and biological evaluation of a novel series of sulfonanilide analogues derived from the COX-2 selective inhibitor NS-398 are described. The compounds suppress aromatase enzyme activity in SK-BR-3 breast cancer cells in a ...