1, 1-Difluoro-1-alkenes are unique compounds with unusually high electrophilicity from the gem-difluorovinyl group, and recently have drawn many synthetic and theoretical endeavors.[1] gem-Difluorovinyl functionality has been known to act as a bioisostere for aldehydes and ketones,[2] and it is critical to many biologically active molecules such as enzyme inhibitors [1, 3] and pesticides.[4] 1, 1-Difluoro-1-alkenes are also useful synthetic ...
