Synthesis and Hybridization Studies of 2'-Amino-α-L-LNA and Tetracyclic “Locked LNA”

TS Kumar, AS Madsen, J Wengel…

文献索引：Boesen, Thomas; Madsen, Christian; Pedersen, Daniel Sejer; Nielsen, Brian M; Petersen, Asger B; Petersen, Michael A; Munck, Michael; Henriksen, Ulla; Nielsen, Claus; Dahl, Otto Organic and biomolecular chemistry, 2004 , vol. 2, # 8 p. 1245 - 1254

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被引用次数: 48

摘要

A convergent route to a new class of locked nucleic acids, ie, 2'-amino-α-L-LNA, has been developed. The optimized synthetic route to the corresponding phosphoramidite building block of thymine proceeds in 4% overall yield over 15 steps from the starting diol. Crucial