Synthesis and biological properties of S-deoxo analogs of the natural antibiotic sparsomycin

RG Melik-Ogandzhanyan, AA Arutyunyan…

文献索引：Melik-Ogandzhanyan, R. G.; Arutyunyan, A. A.; Stepanyan, G. M.; Arsenyan, F. G.; Garibdzhanyan, B. T.; et al. Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 9 p. 698 - 702 Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 9 p. 1095 - 1098

全文：HTML全文

被引用次数: 0

摘要

The synthesis of acid III described in the literature consists in the saponification of ethyl ester IV, obtained from methacil-5-aldehyde and carbethoxymethylenetriphenylphosphorane via the Wittig reaction [ii]. In order to simplify the synthesis we, in analogy with the method described in the literature, initially obtained acid III from methacil-5-aldehyde and then esterified it [9]. By chlorination of ethyl ester IV with POCl3-diethylanine we obtained ...