High rates and substrate selectivities in water by polyvinylimidazoles as transaminase enzyme mimics with hydrophobically bound pyridoxamine derivatives as …

R Skouta, S Wei, R Breslow

文献索引：Skouta, Rachid; Wei, Sujun; Breslow, Ronald Journal of the American Chemical Society, 2009 , vol. 131, # 43 p. 15604 - 15605

全文：HTML全文

被引用次数: 21

摘要

Free-radical polymers of 4-vinylimidazole and copolymers with 1-dodecyl-4-vinylimidazole were used as enzyme mimics to transaminate pyruvic acid to alanine, phenylpyruvic acid to phenylalanine, and indole-3-pyruvic acid to tryptophan in water at pH 7.5 and 20° C using pyridoxamines carrying hydrophobic side chains as coenzyme mimics. The best enzyme mimic accelerated the transamination of indole-3-pyruvic acid by a factor of 4 million ...