Potential antisecretory antidiarrheals. 1.. alpha. 2-Adrenergic aromatic aminoguanidine hydrazones

…, RG Bianchi, P Palicharla, EL Sanguinetti…

文献索引：Pitzele; Moormann; Gullikson; Albin; Bianchi; Palicharla; Sanguinetti; Walters Journal of Medicinal Chemistry, 1988 , vol. 31, # 1 p. 138 - 144

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被引用次数: 11

摘要

Guanabenz, a centrally acting antihypertensive agent, has been shown to have intestinal antisecretory properties. A series of aromatic aminoguanidine hydrazones was made in an effort to separate the antisecretory and cardiovascular activities. Benzaldehyde, naphthaldehyde, and tetralone derivatives were synthesized. The compounds were evaluated in the cholera toxin treated ligated jejunum of the rat and in the Ussing chamber ...