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Pyrrolopyridine analogs of nalidixic acid. 1. Pyrrolo [2, 3??b] pyridines

…, G Tarzia, P Ferrari, G Tuan

文献索引:Toja; Tarzia; Ferrari; Tuan Journal of Heterocyclic Chemistry, 1986 , vol. 23, # 5 p. 1555 - 1560

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被引用次数: 16

摘要

Abstract A series of 4, 7-dihydro-4-oxo-1H-pyrrolo [2, 3-b] pyridine-5-carboxylic acids was synthesized from ethyl 5-methyl (or 5H)-2-aminopyrrole-3-carboxylate. The starting pyrroles were obtained by reaction of carbethoxyacetamidine with bromoacetone or chloroacetaldehyde. One compound (10) showed antibacterial activity in vitro.