Convenient One-Pot Synthesis of 8-Substituted Xanthines from 6-Amino-5-Nitrosouracils

…, SR Schow, RT Lum, MG Nelson, CR Melville

文献索引：Moore; Schow; Lum; Nelson; Melville Synthesis, 1999 , # 7 p. 1123 - 1126

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被引用次数: 6

摘要

Abstract: C-8 substituted 1, 3-dipropylxanthines are typically prepared by reduction of the aminonitrosouracil 2 to the corresponding diamine, which is acylated and then treated with strongly basic or dehydrating reagents to afford the xanthine 1. Working to discover a milder, more efficient, reaction sequence it was found that the C-6 amino group of 2 can be acylated, and that treatment of the resulting compounds with Sn (OAc) 2 gave 8- ...