Bisguanidine, bis (2-aminoimidazoline), and polyamine derivatives as potent and selective chemotherapeutic agents against Trypanosoma brucei rhodesiense. …
C Dardonville, R Brun
文献索引：Dardonville, Christophe; Brun, Reto Journal of Medicinal Chemistry, 2004 , vol. 47, # 9 p. 2296 - 2307
The in vitro screening for trypanocidal activity against Trypanosoma brucei rhodesiense of an in-house library of 62 compounds [ie alkane, diphenyl, and azaalkane bisguanidines and bis (2-aminoimidazolines)], which were chosen for their structural similarity to the trypanocidal agents synthalin (1, 10-decanediguanidine) and 4, 4'- diguanidinodiphenylmethane and the polyamine N 1-(3-amino-propyl) propane-1, 3- ...
