Abstract: A synthesis of some 1, 2-(hetero) arylsubstituted ethanone and 1, 3 (hetero) aryl substituted 3-hydroxypropenone derivatives, designed as potential HIV-1 integrase inhibitors, is reported. The microwave-assisted synthesis was applied in several reactions achieving reductions in reaction times and high yields. All compounds prepared were tested to explore their potential anti-HIV activity.
