Role of O-acetyltransferase in activation of oxidised metabolites of the genotoxic environmental pollutant 1-nitropyrene

PF Rosser, P Ramachandran, R Sangaiah…

文献索引：Rosser; Ramachandran; Sangaiah; Austin; Gold; Ball Mutation Research - Genetic Toxicology, 1996 , vol. 369, # 3-4 p. 209 - 220

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被引用次数: 16

摘要

The genotoxic environmental contaminant 1-nitropyrene is metabolised in mammalian systems by pathways more complex than the straightforward nitroreduction which accounts for most of its biological activity in bacteria. In order to evaluate the role of O- acetyltransferase (OAT) activity in generation of genotoxic intermediates from 1-nitropyrene, the mutagenecity of the major primary oxidised metabolites of 1-nitropyrene was ...