Journal of medicinal chemistry

Functional cholesteryl binding agents: synthesis, characterization, and evaluation of antibody binding to modified phospholipid vesicles

TR Carroll, A Davison, AG Jones

文献索引：Carroll, Timothy R.; Davison, Alan; Jones, Alun G. Journal of Medicinal Chemistry, 1986 , vol. 29, # 10 p. 1821 - 1826

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被引用次数: 12

摘要

A series of functionalized cholesteryl derivatives were synthesized. The various lipophilic protein modification agents were analyzed for their protein binding ability. The binding of human IgG, labeled with 1251, to modified phospholipid vesicles was ascertained. Two agents performed well. These were cholest-5-en-3~-yl5-carboxypentyl ether succinimido ester and cholest-5-en-3P-yl 6-carboxyhexyl ether succinimido ester.