Isopropyl amide derivatives of potent and selective muscarinic M 2 receptor antagonists

…, S Dugar, JW Clader, WJ Greenlee, V Ruperto…

文献索引：Palani, Anandan; Dugar, Sundeep; Clader, John W.; Greenlee, William J.; Ruperto, Vilma; Duffy, Ruth A.; Lachowicz, Jean E. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 7 p. 1791 - 1794

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被引用次数: 8

摘要

Low molecular weight amide derivatives were synthesized and evaluated as M2 receptor antagonists for the treatment of Alzheimer's disease. Isopropyl amides 19 and 31 are highly potent, selective and low molecular weight M2 receptor antagonists with structural features different from our clinical candidate 1.