Structure based medicinal chemistry approach to develop 4-methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agent

A Thiyagarajan, MTA Salim, T Balaraju, C Bal…

文献索引：Thiyagarajan, Anandarajan; Salim, Mohammed T.A.; Balaraju, Tuniki; Bal, Chandralata; Baba, Masanori; Sharon, Ashoke Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 24 p. 7742 - 7747

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被引用次数: 7

摘要

The structure-based approaches were implemented to design and rationally select the molecules for synthesis and anti-HCV activity evaluation. The systematic structure–activity relationships of previously discovered molecules (types I, II, III) were analyzed to design new molecules (type IV) by bioisosteric replacement of the amino group. The ligand conformation, binding mode studies and drug like properties were major determinant for ...