Approach to a better understanding and modeling of (S)-dihydrofuran-2-yl,(S)-tetrahydrofuran-2-yl-, and furan-2-yl-β-dialkylaminoethanol ligands for enantioselective …
This paper outlines our efforts to study the influence of an oxygen atom adjacent to the stereogenic center of β-aminoalcohol derivatives used as ligands for catalysts in the asymmetric alkylation of aldehydes. Thirty-four enantiomerically pure (S)-dihydrofuran-2- yl,(S)-tetrahydrofuran-2-yl-, and furan-2-yl-β-dialkylamino alcohols have been prepared from 1, 4: 3, 6-dianhydromannitol, 1, 4: 3, 6-dianhydrosorbitol, and aminoacids, and then have ...
