Relative ortho??directing power of fluorine, chlorine and methoxy group for the metalation reaction in the diazine series. Diazines XXXV

…, G Queguiner, M Darabantu, T Lequeux…

文献索引：Toudic, Frederic; Turck, Alain; Ple, Nelly; Queguiner, Guy; Darabantu, Mircea; Lequeux, Thierry; Pommelet, Jean Claude Journal of Heterocyclic Chemistry, 2003 , vol. 40, # 5 p. 855 - 860

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被引用次数: 17

摘要

Introduction. Some years ago (1996) [1], we studied the relative ortho-directing power of the methoxy group and the chlorine atom for the metalation reaction in the diazine series. The substrate was 3-chloro-6-methoxypyridazine and various hindered alkylamides were used as metalat- ing agents. In this paper we have extended the compari- son to 2-chloro and -fluoro-6-methoxypyrazine and to 3-fluoro-6-chloropyridazine. At first we shall recall the main results in the benzene ...