B-[2-(Trimethylsilyl) ethynyl]-9-borabicyclo [3.3. 1] nonane. A new organoboron reagent for the preparation of propargylic alcohols

JC Evans, CT Goralski, DL Hasha

文献索引：Evans, Jonathan C.; Goralski, Christian T.; Hasha, Dennis L. Journal of Organic Chemistry, 1992 , vol. 57, # 10 p. 2941 - 2943

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被引用次数: 18

摘要

Propargylic alcohols are key intermediates in the synthesis of many natural products including the prostaglandins, l steroids, 2 carotenoids, 3 and leukotrienes.'Researchers in this area have focused their attention mainly on the addition of alkynylmetals (Li, Na, K, Mg, Zn, and Al) to aldehydes as a means of preparing propargylic alcoho1s, 6 but these alkynylmetal reagents are not without limitations.