Enzymic synthesis of β-glucuronides of estradiol, ethynylestradiol and other phenolic substrates on a preparative scale employing UDP-glucuronyl transferase

B Werschkun, A Wendt, J Thiem

文献索引：Werschkun, Barbara; Wendt, Andreas; Thiem, Joachim Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 18 p. 3021 - 3023

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被引用次数: 9

摘要

By incubation of bovine liver UDP-glucuronyl transferase with various phenolic aglycone substrates, preparation of the corresponding β-glucuronides could be achieved in milligram quantities. Concomitantly, simple access was generated to estrogen steroid glucuronides of great biological importance. In terms of experimental feasibility, direct application of the commercially available crude microsomal product was compared to and proven to be ...