Synthesis

General and Versatile Approach to the Synthesis of Optically Active 5-Alkylpiperazine-2-carboxylic Acids

M Falorni, G Giacomelli, M Satta, S Cossu

文献索引：Falorni; Giacomelli; Satta; Cossu Synthesis, 1994 , # 4 p. 391 - 395

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被引用次数: 10

摘要

General and convenient syntheses of optically active 5-alkylpiperazine-2-carboxylic acids are described. The methods are based on cyclization of L-or D-serine with oz-amino acids and occur without loss of optical purity. The presented procedures are based on readily available starting materials and can be arranged for multigram quantities.