Evaluation of structural effects on 5-HT 2A receptor antagonism by aporphines: Identification of a new aporphine with 5-HT 2A antagonist activity

S Ponnala, J Gonzales, N Kapadia, HA Navarro…

文献索引：Ponnala, Shashikanth; Gonzales, Junior; Kapadia, Nirav; Navarro, Hernan A.; Harding, Wayne W. Bioorganic and Medicinal Chemistry Letters, 2014 , vol. 24, # 7 p. 1664 - 1667

全文：HTML全文

被引用次数: 9

摘要

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... A set of aporphine analogs related to nantenine was evaluated for antagonist activity at 5-HT 2A and α 1A adrenergic receptors. ... With regards to 5-HT 2A receptor antagonism, a C2 allyl group is detrimental to activity. The chiral center of nantenine is not important for 5-HT 2A ...