Journal of medicinal chemistry

Isoxazole anthelmintics

JB Carr, HG Durham, DK Hass

文献索引：Carr,J.B. et al. Journal of Medicinal Chemistry, 1977 , vol. 20, p. 934 - 939

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被引用次数: 54

摘要

Hydrogenolysis of a mixture of 18a and 18b as described above gave a mixture of 2a and 2b as a colorless glass (90%): TLC (10% MeOHCHC13) shows two bands at lower R, than starting material; IR and'H NMR as expected; attempts to crystallize the mixture were unsuccessful. The diastereomers were separated by preparative TLC (20% MeOHCHClJ, giving hygroscopic glasses. The greater R, diastereomer was designated 2b:[a] 25589- ...