Antitumor agents 270. Novel substituted 6-phenyl-4H-furo [3, 2-c] pyran-4-one derivatives as potent and highly selective anti-breast cancer agents

…, K Nakagawa-Goto, PC Wu, SL Morris-Natschke…

文献索引：Dong, Yizhou; Shi, Qian; Nakagawa-Goto, Kyoko; Wu, Pei-Chi; Morris-Natschke, Susan L.; Brossi, Arnold; Bastow, Kenneth F.; Lang, Jing-Yu; Hung, Mien-Chie; Lee, Kuo-Hsiung Bioorganic and Medicinal Chemistry, 2010 , vol. 18, # 2 p. 803 - 808

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被引用次数: 17

摘要

6-Phenyl-4H-furo [3, 2-c] pyran-4-one derivatives based on neo-tashinlactone (1) were synthesized and evaluated as novel anti-breast cancer agents. Compounds 10–13, 23, 25, and 27 showed potent inhibition against the SK-BR-3 breast cancer cell line. Importantly, 25 and 27 showed the highest cancer cell line selectivity, being approximately 100–250-fold more potent against SK-BR-3 (ED50 0.28 and 0.44 μM, respectively) compared with other ...