Abstract A new catalytic asymmetric Henry reaction has been developed that uses a C 1- symmetric chiral aminopyridine ligand derived from camphor and picolylamine. A variety of aromatic, heteroaromatic, aliphatic, and unsaturated aldehydes react with nitromethane and other nitroalkanes in the presence of DIPEA (1.0 equiv), Cu (OAc) 2⋅ H 2 O (5 mol%), and an aminopyridine ligand (5 mol%) to give the expected products in high yields (up to 99%) ...
