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Design, synthesis, and structure–activity relationships of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands

T Okubo, R Yoshikawa, S Chaki, S Okuyama…

文献索引:Okubo, Taketoshi; Yoshikawa, Ryoko; Chaki, Shigeyuki; Okuyama, Shigeru; Nakazato, Atsuro Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 13 p. 3569 - 3580

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被引用次数: 30

摘要

The peripheral benzodiazepine receptor (PBR) is pharmacologically distinct from the central benzodiazepine receptor (CBR) and has been identified in a wide range of peripheral tissues as well as in the central nervous system. Although numerous studies have been performed of it, the physiological roles and functions of the PBR are still unclear. In the present study, in exploring new types of ligands for PBR, we found that a new series of ...