Novel dual inhibitors of calpain and lipid peroxidation

S Auvin, B Pignol, E Navet, D Pons, JG Marin…

文献索引：Auvin, Serge; Pignol, Bernadette; Navet, Edith; Pons, Dominique; Marin, Jean-G.; Bigg, Dennis; Chabrier, Pierre-E. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 14 p. 3825 - 3828

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被引用次数: 25

摘要

A series of molecules with dual inhibitory activities on calpain and lipid peroxidation were synthesized. These hybrid compounds were built on the calpain pharmacophore 2- hydroxytetrahydrofuran linked to a set of antioxidants via a l-leucine linker. Compound 7, the most potent in cellular calpain and lipid peroxidation inhibitions, provided effective protection against glial cell death induced by maitotoxin.