Tetrahedron

Assembly of N, N-disubstituted-N′-arylureas via a copper-catalyzed one-pot three-component reaction of aryl bromides, potassium cyanate, and secondary amines

H Yin, B Chen, X Zhang, X Yang, Y Zhang, Y Jiang…

文献索引：Yin, Hongfei; Chen, Bing; Zhang, Xiaojing; Yang, Xinye; Zhang, Yihua; Jiang, Yongwen; Ma, Dawei Tetrahedron, 2013 , vol. 69, # 26 p. 5326 - 5330

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被引用次数: 3

摘要

A three-component reaction of aryl bromides, potassium cyanate, and secondary amines takes place at 110° C in MeCN under the catalysis of Cu2O and 2-(2, 6- dimethylphenylamino)-2-oxoacetic acid potassium salt, giving N, N-disubstituted-N′- arylureas in good to excellent yields. A number of functionalized aryl bromides and secondary amines were compatible with these conditions, and thereby providing a facile ...