A 4′-O-sulphated analogue of wedeloside, a new flavanone, 7, 4′-dihydroxy-8, 3′- dimethoxyflavanone and its related chalcone, together with the 4′-O-β-d-glucopyranoside of the latter, and a number of known compounds were isolated from the aerial parts of Wedelia asperrima. Their structures were established by spectroscopic techniques and by synthesis of the flavanone and chalcone.