Design and synthesis of potent antileishmanial cycloalkylidene-substituted ether phospholipid derivatives

T Calogeropoulou, P Angelou, A Detsi…

文献索引：Calogeropoulou, Theodora; Angelou, Panagiotis; Detsi, Anastasia; Fragiadaki, Irene; Scoulica, Effie Journal of Medicinal Chemistry, 2008 , vol. 51, # 4 p. 897 - 908

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被引用次数: 23

摘要

Two series of novel ether phospholipids (EPs) have been synthesized. The first includes cyclodecylidene-or cyclopentadecylidene-substituted EPs carrying N, N, N- trimethylammonium or N-methylpiperidino or N-methylmorpholino head groups. The second series encompasses more rigid head groups in combination with cycloalkylidene moieties in the lipid portion. In addition, hydrogenated derivatives were obtained. All the new ...