AN IMPROVED PREPARATION OF QUINUCLIDIN-3-THIOL

SD Aster, SS Yang, GD Berger

文献索引：Aster, S. D.; Yang, S. S.; Berger, G. D. Organic Preparations and Procedures International, 1991 , vol. 23, # 5 p. 658 - 660

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摘要

As a modification of Shaw's procedure, hydrogen sulfide is condensed (-70') into isopropanol in a glass bomb. 3 The quinuclidinone is added and the sealed reaction mixture stirred at 40'for 15 hrs. Longer reaction times or higher temperatures resulted in less workable reaction mixtures. Our procedure increases the yield of the condensation product (80%) and eliminates the prolonged hydrogen sulfide additions. Reduction with sodium ...