Trifluoromethylation of Ketones and Aldehydes with Bu3SnCF3

…, KJ Bonney, MC Nielsen, F Schoenebeck

文献索引：Sanhueza, Italo A.; Bonney, Karl J.; Nielsen, Mads C.; Schoenebeck, Franziska Journal of Organic Chemistry, 2013 , vol. 78, # 15 p. 7749 - 7753

全文：HTML全文

被引用次数: 10

摘要

The (trifluoromethyl) stannane reagent, Bu3SnCF3, was found to react under CsF activation with ketones and aldehydes to the corresponding trifluoromethylated stannane ether intermediates at room temperature in high yield. Only a mildly acidic extraction (aqueous NH4Cl) is required to release the corresponding trifluoromethyl alcohol products. The protocol is compatible with acid-sensitive functional groups.