Discovery of pyrrolidine-based β-secretase inhibitors: Lead advancement through conformational design for maintenance of ligand binding efficiency

SJ Stachel, TG Steele, A Petrocchi…

文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 240 - 244

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被引用次数: 20

摘要

... Bioorganic & Medicinal Chemistry Letters. ... a Department of Medicinal Chemistry, Merck Research Laboratories, Merck & Co., PO Box 4, West Point, PA 19486, USA; b ... Alzheimer's disease (AD) is rapidly becoming one of the largest unmet medical needs in the developed world. ...