Tetrahedron letters

The indium (III) chloride-catalyzed von Pechmann reaction: a simple and effective procedure for the synthesis of 4-substituted coumarins

DS Bose, AP Rudradas, MH Babu

文献索引：Subhas Bose; Rudradas; Hari Babu, Mereyala Tetrahedron Letters, 2002 , vol. 43, # 50 p. 9195 - 9197

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被引用次数: 187

摘要

The von Pechmann reaction is a venerable reaction and it is one of the most simple and straightforward methods used to produce coumarins. Classically, the process consists of the condensation of phenols with β-ketoesters in the presence of a variety of reagents and gives good yields of 4-substituted coumarins. 7 Several acid catalysts have been used in the von Pechmann reaction including sulfuric acid, 4a aluminium chloride, 8 phosphorus pentoxide, 9., and ...