Phenylbenzopyrones structure-activity studies identify betuletol derivatives as potential antitumoral agents

S Rubio, J Quintana, M López, JL Eiroa, J Triana…

文献索引：Rubio, Sara; Quintana, Jose; Lopez, Mariana; Eiroa, Jose Luis; Triana, Jorge; Estevez, Francisco European Journal of Pharmacology, 2006 , vol. 548, # 1-3 p. 9 - 20

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被引用次数: 49

摘要

We have analyzed the cytotoxicity of 22 compounds with a phenylbenzo-γ-pirone core structure, most of them obtained from natural sources, in five human tumor cell lines (HL-60, A431, SK-OV-3, HeLa and HOS). Betuletol 3-methyl ether and its diacetate were the most cytotoxic compounds. The HL-60 cell line was especially sensitive to these compounds, with IC50 values of approximately 1 μM. Treatment of HL-60 cells with betuletol 3-methyl ether ...