RSC Advances

Regioselective ortho-carboxylation of phenols catalyzed by benzoic acid decarboxylases: a biocatalytic equivalent to the Kolbe–Schmitt reaction

C Wuensch, J Gross, G Steinkellner, A Lyskowski…

文献索引：Wuensch, Christiane; Gross, Johannes; Steinkellner, Georg; Lyskowski, Andrzej; Gruber, Karl; Glueck, Silvia M.; Faber, Kurt RSC Advances, 2014 , vol. 4, # 19 p. 9673 - 9679

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被引用次数: 8

摘要

The enzyme catalyzed carboxylation of electron-rich phenol derivatives employing recombinant benzoic acid decarboxylases at the expense of bicarbonate as CO2 source is reported. In contrast to the classic Kolbe–Schmitt reaction, the biocatalytic equivalent proceeded in a highly regioselective fashion exclusively at the ortho-position of the phenolic directing group in up to 80% conversion. Several enzymes were identified, which ...