Novel benzofurans with 99mTc complexes as probes for imaging cerebral β-amyloid plaques

M Ono, Y Fuchi, T Fuchigami, N Kobashi…

文献索引：Ono, Masahiro; Fuchi, Yasufumi; Fuchigami, Takeshi; Kobashi, Nobuya; Kimura, Hiroyuki; Haratake, Mamoru; Saji, Hideo; Nakayama, Morio ACS Medicinal Chemistry Letters, 2010 , vol. 1, # 8 p. 443 - 447

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被引用次数: 13

摘要

Two novel benzofuran derivatives coupled with 99mTc complexes were tested as probes for imaging cerebral β-amyloid plaques using single photon emission tomography. Although both derivatives bound to Aβ (1− 42) aggregates, 99mTc-BAT-BF showed higher affinity than 99mTc-MAMA-BF. In sections of brain tissue from an animal model of AD, 99mTc-BAT-BF clearly labeled β-amyloid plaques. In biodistribution experiments using normal mice, ...