Anti-Pneumocystis carinii pneumonia activity of dicationic carbazoles

…, FA Tanious, J Spychala, BC Bender, JE Hall…

文献索引：Patrick; Boykin; Wilson; Tanious; Spychala; Bender; Hall; Dykstra; Ohemeng; Tidwell European Journal of Medicinal Chemistry, 1997 , vol. 32, # 10 p. 781 - 793

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被引用次数: 66

摘要

A series of 2, 7-and 3, 6-bis cationic carbazoles was synthesized and evaluated for activity against a rat model of Pneumocystis carinii pneumonia (PCP). The compounds were also tested for inhibition of topoisomerase II and binding to DNA. Several of the compounds proved to be more potent and less toxic than a standard anti-PCP drug (pentamidine). While no quantitative correlation was seen between anti-PCP activity, topoisomerase inhibition ...