The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors

M Xin, J Wen, F Tang, C Tu, H Shen, X Zhao

文献索引：Xin, Minhang; Wen, Jun; Tang, Feng; Tu, Chongxing; Shen, Han; Zhao, Xinge Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6777 - 6783

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被引用次数: 19

摘要

Abstract Hedgehog signaling pathway inhibitors are emerging as new therapeutic intervention against cancer. A novel series of N-(2-pyrimidinylamino) benzamide derivatives as hedgehog signaling pathway inhibitors were designed and synthesized. Most compounds presented significant inhibitory effect on hedgehog signaling pathway, among which 21 compounds exhibited more potent than vismodegib. Furthermore, compound 6a ...