Abstract Selective hydrolysis of 2-amino-4, 6-dichloro-5-pyrimidinecarboxaldehyde, 2, gave 2-amino-4-chloro-1, 6-dihydro-6-oxo-5-pyrimidinecarboxaldehyde, 5. The oxime of 2 rearranged to 2-amino-4-chloro-1, 6-dihydro-6-oxo-5-pyrimidinecarbonitrile, 8. Reaction of 8 with 4-phenylbutylamine resulted in the displacement of the 4-chloro atom to give compound 9. Hydrolysis of the cyano function of 9 gave amides 12, 13, and 14 depending on reaction ...
